
ubpbio/GDC-0068 (RG7440, Ipatasertib)/F6171/25 mg
商品编号:
F6171
市场价:
¥5600.00
美元价:
3360.00
产品分类:
酶抑制剂
公司分类:
Enzyme_Inhibitors
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
GDC-0068(RG7440orIpatasertib)isanovel,ATP-competitiveAkt1/2/3inhibitorwithIC50valuesof5nM,18nMand8nM,respectively.GDC-0068selectivelyinhibitscellcycleprogressionandviABIlityofcancercelllinesdrivenbyPI3K/Aktsignalingpathway,includingthosewithdefectsofthetumorsuppressorPTEN,oncogenicmutationsinPIK3CA,andamplificationofHER2.GDC-0068blocksthephosphorylationofmultipledownstreamtargetsofAktinhumancancercelllines.
AdditionalInformation
ProductName: | GDC-0068(RG7440,Ipatasertib) |
---|---|
AlsoKnownAs: | Ipatasertib,(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one |
CatalogNo.: | F6171 |
Size: | 25mg |
CAS: | 1001264-89-6 |
Formula: | C24H32ClN5O2 |
MolecularWeight: | 458Da |
Form: | Lyophilizedpowder |
QualityAssurance: | >98%byHPLCandNMR |
Source: | Synthetic |
Storage: | EligIBLeforroomtemperatureshipping.Storeat-80°Cuponreceiving |
PDFDataSheet: | DownloadPDFdatasheet |
Image(s): | N/A |
ShippingMethod: | Roomtemperatureshipping |
References: | BlakeJF,etal.(2012)JMedChem.55(18):8110-27. |