ubpbio/VE-821/F8131/25 mg

来自 : 发布时间：2025-06-14

VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to radiation, also sensitizes cancer cells to chemotherapy.

Additional Information

Product Name: Also Known As: Catalog No.: Size: CAS: Formula: Molecular Weight: Form: Quality Assurance: Source: Storage: PDF Data Sheet: Image(s): Shipping Method: References:

VE-821

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide

F8131

25 mg

1232410-49-9

C18H16N4O3S

368.41 Da

Lyophilized powder

>98% by HPLC and NMR

Synthetic

Eligible for room temperature shipping. Store at -80°C upon receiving

Download PDF datasheet

N/A

Room temperature shipping

1. Reaper PM, et al. (2011) Nat Chem Biol, 7(7), 428-430.2. Prevo, R, et al. (2012) Cancer Biol Ther, 13(11) 1072-1081.3. Huntoon, CJ, et al. (2013) Cancer Res, 73(12) 3683-3691.

Details

VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to radiation, also sensitizes cancer cells to chemotherapy.Solubility: 20 mg/ml in DMSO